SLC22A1 polyclonal antibody
产品名称： SLC22A1 polyclonal antibody
英文名称： SLC22A1 polyclonal antibody
产品编号： PAB15968
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SLC22A1.
- Immunogen:
- A synthetic peptide corresponding to C-terminus of human SLC22A1.
- Sequence:
- DWNQSALSCVDPLASLA
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Storage Buffer:
- In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).
Muller J, Lips KS, Metzner L, Neubert RH, Koepsell H, Brandsch M.Biochem Pharmacol. 2005 Dec 5;70(12):1851-60. Epub 2005 Nov 2.
- 2.
- Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.
Kimura N, Masuda S, Tanihara Y, Ueo H, Okuda M, Katsura T, Inui K.Drug Metab Pharmacokinet. 2005 Oct;20(5):379-86.
- 3.
- Regulation of the human organic cation transporter hOCT1.
Ciarimboli G, Struwe K, Arndt P, Gorboulev V, Koepsell H, Schlatter E, Hirsch JR.J Cell Physiol. 2004 Dec;201(3):420-8.
- Application Image
- Western Blot
- ELISA
- Entrez GeneID:
- 6580
- Gene Name:
- SLC22A1
- Gene Alias:
- HOCT1,OCT1,oct1_cds
- Gene Description:
- solute carrier family 22 (organic cation transporter), member 1
- Omim ID:
- 602607
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq
- Other Designations:
- OTTHUMP00000017537,organic cation transporter 1,solute carrier family 22 member 1
- Related Disease
- Breast cancer
- Cholestasis
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- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Drug Toxicity
- Genetic Predisposition to Disease
- Hyperparathyroidism, Secondary
- Hypertension
- Kidney Failure, Chronic
- Leukemia, chronic myeloid
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Neovascularization, Pathologic
- Tobacco Use Disorder