中文名称 肿瘤坏死因子受体2重组兔单克隆抗体 
别    名 TNF Receptor II; CD120b; p75; p75TNFR; p80 TNF alpha receptor; p80 TNF-alpha receptor; TBP-2; TBPII; TNF R2; TNF R75; TNF-R2; TNF-RII; TNFR-II; TNFR80; TNFRII; TNFRSF1B; TNR1B_HUMAN; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor type II; Tumor necrosis factor-binding protein 2.   
研究领域 肿瘤  细胞生物  神经生物学  信号转导  细胞凋亡  细胞膜受体   
抗体来源 Rabbit 
克隆类型 Monoclonal 
克 隆 号 7D3 
交叉反应 (predicted: Human, Mouse, Rat, ) 
产品应用 WB=1:500-2000 IP=1:10-50 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. 
分 子 量 46kDa 
细胞定位 细胞膜 分泌型蛋白  
性    状 Liquid 
浓    度 1mg/ml 
免 疫 原 KLH conjugated synthetic peptide derived from human TNFR2:  
亚    型 IgG 
纯化方法 affinity purified by Protein A 
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 
PubMed PubMed 
产品介绍 The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
 
Function:
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that