Recombinant Mouse soluble Tumor Necrosis Factor Receptor Type II/TNFRSF1B (Mouse sTNF RII/TNFRSF1B)
产品名称： Recombinant Mouse soluble Tumor Necrosis Factor Receptor Type II/TNFRSF1B (Mouse sTNF RII/TNFRSF1B)
英文名称： Recombinant Mouse soluble Tumor Necrosis Factor Receptor Type II/TNFRSF1B (Mouse sTNF RII/TNFRSF1B)
产品编号： 90626ES08
产品价格： 0
产品产地： Yeasen
品牌商标： Yeasen
更新时间： 2023-08-17T13:40:59
使用范围： null
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Product Information
Product Name
Cat#
Size
Price（¥）
Recombinant Mouse soluble Tumor Necrosis Factor Receptor Type II/TNFRSF1B (Mouse sTNF RII/TNFRSF1B)
90626ES08
5 μg
815
90626ES60
100 μg
7,865
90626ES76
500 μg
20,425
Product Description
Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa. The TNF receptor superfamily is comprised of structurally related receptors that bind to TNF-related ligands and regulate numerous processes such as immune cell activation and apoptosis. Receptors in this superfamily are characterized by the presence of a cysteine-rich region in their extracellular domain (ECD). Mouse TNF RII contains four cysteine-rich repeats in its ECD, which shares 58% and 84% amino acid sequence identity with the human and rat orthologs, respectively. Several receptors in the TNF superfamily also contain intracellular death domains (DDs) that recruit caspase-interacting proteins to initiate apoptosis upon ligand binding. Those receptors that lack DDs, like TNF RII, bind TNF Receptor-associated Factors, which transduce signals generated by activation of these receptors.
Product Properties
Synonyms
CD120b antigen; CD120b; Etanercept; p75 TNF receptor; p75TBPII; p75TNFR
Accession
P25119
GeneID
21938
Source
E.coli-derived Mouse sTNF RII/TNFRSF1B, Val23-Gly258.
Molecular Weight
Approximately 25.3 kDa.
AA Sequence
VPAQVVLTPY KPEPGYECQI SQEYYDRKAQ MCCAKCPPGQ YVKHFCNKTS DTVCADCEAS MYTQVWNQFR TCLSCSSSCT TDQVEIRACT KQQNRVCACE AGRYCALKTH SGSCRQCMRL SKCGPGFGVA SSRAPNGNVL CKACAPGTFS DTTSSTDVCR PHRICSILAI PGNASTDAVC APESPTLSAI PRTLYVSQPE PTRSQPLDQE PGPSQTPSIL TSLGSTPIIE QSTKGG
Tag
None
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity
> 97% by SDS-PAGE and HPLC analyses.
Biological Activity
The ED50 as determined by its ability to inhibit the TNF-α mediated cytotoxicity in the L-929 cells is less than 2 μg/mL, corresponding to a specific activity of > 500 IU/mg in the presence of 0.1 ng/mL of rMuTNF-α. Fully biologically active when compared to standard.
Endotoxin
< 0.1 EU per 1μg of the protein by the LAL method.
Formulation
Lyophilized from a 0.2 µm filtered solution in PBS, pH 7.4.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.
Shipping and Storage
The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Cautions
1. Avoid repeated freeze-thaw cycles.
2. For your safety and health, please wear lab coats and disposable gloves for operation.
3. For research use only!
HB220425