分子量：Calculated MW: 30kDa/35kDa/39kDa/41kDa/43kDa
Observed MW: 38-44kDa

细胞定位：Cell projection, Chromosome, Cytoplasm, Midbody, Myelin membrane, Nucleus, Perikaryon, centriole, centrosome, cytoskeleton, growth cone, microtubule organizing center, perinuclear region, spindle

稀释方法：WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:10 - 1:100

总结：This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.