NCKAP1抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
NCKAP1抗体

NCKAP1抗体

商家询价

产品名称： NCKAP1抗体

英文名称： NCKAP1Antibody

产品编号： XY 12140-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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NCKAP1抗体Applications

In-house applications ELISA, WB, IHC     Application not tested? Please see our Guarantee.
Published applications WB Publications 2 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human
Images
Prev1NextView more validation data
  • 12140-1-AP;mouse brain tissuemouse brain tissue were subjected to SDS PAGE followed by western blot with 12140-1-AP(NAP1;NCKAP1 antibody) at dilution of 1:1000
  • 12140-1-AP;human heart tissueImmunohistochemistry of paraffin-embedded human heart tissue slide using 12140-1-AP( NAP1;NCKAP1 Antibody) at dilution of 1:50 (under 40x lens)
  • 12140-1-AP;human gliomas tissueImmunohistochemistry of paraffin-embedded human gliomas tissue slide using 12140-1-AP( NAP1;NCKAP1 Antibody) at dilution of 1:50 (under 40x lens)
Positive WB detected in Mouse brain tissue, HepG2 cells, human brain tissue
Positive IHC detected in Human gliomas tissue, human heart tissue
Recommended dilution WB : 1:500-1:5000
IHC : 1:20-1:200
NCKAP1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen InformationNCKAP1抗体
Immunogen NCKAP1 fusion protein ag2788 Full name NCK-associated protein 1
Calculated molecular
weight		 129 kDa Observed molecular 
weight		 115-125 kDa
GenBank accession 
number		 BC015025 Gene ID (NCBI) 10787
Gene symbol NCKAP1 Synonyms FLJ11291, HEM2, KIAA0587, NAP 1, NAP1, NAP125, NCK associated protein 1, NCKAP1, p125Nap1
Background

NCK-associated protein 1 (NCKAP1), also known as NAP1 or HEM2, is encoded by an apoptosis-related gene human NAP1, the expression of which is strongly down-regulated in sporadic Alzheimer's disease (AD). Human NAP1 is predominantly expressed in neuronal cells. Antisense oligo DNA of human NAP1 transcripts was found to induce apoptosis of neuronal cells. Loss of NAP1 function disrupts neuronal differentiation. Likewise, NAP1 plays an essential role in facilitating neuronal cytoskeletal changes underlying the postmigratory differentiation of cortical neurons, a critical step in functional wiring of the cortex. Human NAP1 is also proved to be an orthologue of rat Nap1 which binds to the adaptor molecule NCK in signal transduction.NCKAP1抗体

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