PIK3C2A (N-term) Peptide
产品名称： PIK3C2A (N-term) Peptide
英文名称： PIK3C2A (N-term) Peptide
产品编号： P2983
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PIK3C2A.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PIK3C2A.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Phosphoinositide 3-kinase C2alpha is activated upon smooth muscle cell migration and regulated by alpha(v)beta(3) integrin engagement.
Paulhe F, Perret B, Chap H, Iberg N, Morand O, Racaud-Sultan C.Biochem Biophys Res Commun. 2002 Sep 20;297(2):261-6.
- 2.
- The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles.
Domin J, Gaidarov I, Smith ME, Keen JH, Waterfield MD.J Biol Chem. 2000 Apr 21;275(16):11943-50.
- 3.
- Insulin activates the alpha isoform of class II phosphoinositide 3-kinase.
Brown RA, Domin J, Arcaro A, Waterfield MD, Shepherd PR.J Biol Chem. 1999 May 21;274(21):14529-32.
- Entrez GeneID:
- 5286
- Protein Accession#:
- NP_002636
- Gene Name:
- PIK3C2A
- Gene Alias:
- CPK,DKFZp686L193,MGC142218,PI3-K-C2(ALPHA),PI3-K-C2A
- Gene Description:
- phosphoinositide-3-kinase, class 2, alpha polypeptide
- Omim ID:
- 603601
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq
- Other Designations:
- C2-containing phosphatidylinositol kinase,PI3K-C2alpha