HNF4A polyclonal antibody
产品名称: HNF4A polyclonal antibody
英文名称: HNF4A polyclonal antibody
产品编号: PAB6768
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of HNF4A.
- Immunogen:
- A synthetic peptide corresponding to human HNF4A.
- Sequence:
- RLSKTLVDMDMADY-C
- Host:
- Goat
- Theoretical MW (kDa):
- 51.6, 52.8, 46.6
- Reactivity:
- Human
- Specificity:
- This antibody is expected to recognize the reported isoforms a, b and c (NP_849180.1, NP_000448.3, NP_849181.1 resp.).
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish.
Damcott CM, Hoppman N, Ott SH, Reinhart LJ, Wang J, Pollin TI, O'Connell JR, Mitchell BD, Shuldiner AR.Diabetes. 2004 Dec;53(12):3337-41.
- Entrez GeneID:
- 3172
- Protein Accession#:
- NP_849180.1;NP_000448.3;NP_849181.1
- Gene Name:
- HNF4A
- Gene Alias:
- FLJ39654,HNF4,HNF4a7,HNF4a8,HNF4a9,MODY,MODY1,NR2A1,NR2A21,TCF,TCF14
- Gene Description:
- hepatocyte nuclear factor 4, alpha
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq
- Other Designations:
- HNF4-alpha,OTTHUMP00000031060,OTTHUMP00000031062,hepatic nuclear factor 4 alpha,hepatocyte nuclear factor 4 alpha,transcription factor-14
- Interactome
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Atherosclerosis
- Birth Weight
- Breast cancer
- Breast Neoplasms
- Calcinosis
- Cardiovascular Diseases
- Colitis, Ulcerative
- Coronary Artery Disease
- Diabetes Complications
- Diabetes Mellitus
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetes, Gestational
- Diabetic Nephropathies
- Disease Progression
- Disease Susceptibility
- Dyslipidemias