FITC标记的桥粒芯糖蛋白1
产品名称： FITC标记的桥粒芯糖蛋白1
英文名称： Anti-Desmoglein 1/FITC
产品编号： HZ-6725R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Desmoglein 1/FITC Conjugated antibody
FITC标记的桥粒芯糖蛋白1
| 英文名称 | Anti-Desmoglein 1/FITC |
| 中文名称 | FITC标记的桥粒芯糖蛋白1 |
| 别 名 | Cadherin family member 4; CDHF4; Desmoglein-1; Desmosomal Glycoprotein 1; DG1; DGI; DSG; DSG1; DSG1_HUMAN; Pemphigus Foliaceus Antigen; PPKS1; SPPK1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转录调节因子 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 108kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Desmoglein 1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger. Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Subunit: Binds to JUP/plakoglobin. Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, desmosome. Tissue Specificity: Epidermis, tongue, tonsil and esophagus. DISEASE: Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger. Similarity: Contains 4 cadherin domains. Database links: Entrez Gene: 1828 Human Entrez Gene: 13510 Mouse Omim: 125670 Human SwissProt: Q02413 Human SwissProt: Q61495 Mouse Unigene: 2633 Human Unigene: 37953 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
胞间桥粒连接的组成部分。涉及斑块蛋白和中间丝相互作用介导细胞-细胞粘附。DSG1中的缺陷是掌跖角化型1（SPMK1）的原因（MIM：148700）；也被称为纹状跖角化病。手掌和鞋底皮肤增厚，手掌纵向角化过度病变，每根手指的长度。