phospho-BACE1,磷酸化β分泌酶抗体

产品编号HZ-10192R
英文名称phospho-BACE1 (Ser498)
中文名称磷酸化β分泌酶抗体
别 名BACE1 (phospho-Ser498); BACE1 (phospho-S498); p-BACE1 (Ser498); p-BACE1 (Se498); APP beta secretase; Asp 2; ASP2; Aspartyl protease 2; BACE 1; BACE; Beta secretase 1; Beta secretase; Beta site amyloid beta A4 precursor protein cleaving enzyme; Beta site amyloid precursor protein cleaving enzyme 1; Beta site amyloid precursor protein cleaving enzyme; Beta site APP cleaving enzyme 1; Beta site APP cleaving enzyme; FLJ90568; HSPC104; KIAA1149; Memapsin-2; Memapsin 2; Memapsin2; Membrane associated aspartic protease 2; Transmembrane aspartic proteinase Asp2; BACE1_HUMAN; Beta-secretase 1; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Membrane-associated aspartic protease 2.
说 明 书0.1ml
产品类型磷酸化抗体
phospho-BACE1,磷酸化β分泌酶抗体研究领域免疫学 神经生物学 信号转导 生长因子和激素 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human BACE1 around the phosphorylation site of Ser498
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
phospho-BACE1,磷酸化β分泌酶抗体PubMedPubMed
产品介绍background:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein(APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq].

Function:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Subunit:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.

Post-translational modifications:
Glycosylated.

phospho-BACE1,磷酸化β分泌酶抗体Similarity:
Belongs to the peptidase A1 family.

Gene ID:
23621

Database links:
Entrez Gene: 23621 Human
Entrez Gene: 23821 Mouse
Entrez Gene: 29392 Rat
Omim: 604252 Human
SwissProt: P56817 Human
SwissProt: P56818 Mouse
SwissProt: P56819 Rat
Unigene: 504003 Human
Unigene: 24044 Mouse
Unigene: 207201 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.