AKT2 (phospho S474) Peptide
产品名称: AKT2 (phospho S474) Peptide
英文名称: AKT2 (phospho S474) Peptide
产品编号: P1489
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- 所在区域 : 台湾
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of AKT2.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S474 of human AKT2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Protein kinase B inhibits apoptosis induced by actinomycin D in ECV304 cells through phosphorylation of caspase 8.
Shim D, Kang HY, Jeon BW, Kang SS, Chang SI, Kim HY.Arch Biochem Biophys. 2004 May 15;425(2):214-20.
- 2.
- A family with severe insulin resistance and diabetes due to a mutation in AKT2.
George S, Rochford JJ, Wolfrum C, Gray SL, Schinner S, Wilson JC, Soos MA, Murgatroyd PR, Williams RM, Acerini CL, Dunger DB, Barford D, Umpleby AM, Wareham NJ, Davies HA, Schafer AJ, Stoffel M, O'Rahilly S, Barroso I.Science. 2004 May 28;304(5675):1325-8.
- 3.
- Akt2 expression correlates with prognosis of human hepatocellular carcinoma.
Xu X, Sakon M, Nagano H, Hiraoka N, Yamamoto H, Hayashi N, Dono K, Nakamori S, Umeshita K, Ito Y, Matsuura N, Monden M.Oncol Rep. 2004 Jan;11(1):25-32.
- Applications
- Dot Blot (Peptide)
- Dot blot analysis of AKT2 (phospho S474) polyclonal antibody (Cat # PAB0404) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5 ug/mL. P-Pab : phospho-antibody; P-Peptide : phospho-peptide; NP-Peptide : non-phospho-peptide.
- Entrez GeneID:
- 208
- Protein Accession#:
- NP_001617;P31751
- Gene Name:
- AKT2
- Gene Alias:
- PKBB,PKBBETA,PRKBB,RAC-BETA
- Gene Description:
- v-akt murine thymoma viral oncogene homolog 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq
- Other Designations:
- Murine thymoma viral (v-akt) homolog-2,rac protein kinase beta
- Gene Pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Apoptosis
- B cell receptor signaling pathway
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- Glioma
- Insulin signaling pathway
- Jak-STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- mTOR signaling pathway
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Renal cell carcinoma
- Small cell lung cancer
- T cell receptor signaling pathway
- Tight junction
- Toll-like receptor signaling pathway
- VEGF signaling pathway
- Related Disease
- Adenocarcinoma
- Adenocarcinoma, Papillary
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Drug Toxicity
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- HIV Infections
- Hypercholesterolemia
- Insulin Resistance
- Lipodystrophy
- Lung Neoplasms
- Metabolic Syndrome X
- Neoplasms, Glandular and Epithelial
- Ovarian cancer
- Ovarian Neoplasms