CDK8/CCNC (Human) Recombinant Protein
产品名称： CDK8/CCNC (Human) Recombinant Protein
英文名称： CDK8/CCNC (Human) Recombinant Protein
产品编号： P4663
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human CDK8 (NM_001260, 1 a.a. - 464 a.a.) and CCNC (NM_005190.3, 1 a.a. - 283 a.a.) recombinanat protein with His tag expressed in Sf9 cells.
- Theoretical MW (kDa):
- CDK8: 83.051 , CCNC:
- Form:
- Liquid
- Preparation Method:
- Insect cell (Sf9) expression system
- Purification:
- Immobilized metal affinity chromatography
- Concentration:
- 0.433 ug/uL
- Activity:
- 17 pmol/ug x min
- Storage Buffer:
- In 50 mM Hepes, 100 mM NaCl, pH 7.5. (5 mM DTT, 20% glycerol)
- Storage Instruction:
- Store at -80°C.
Aliquot to avoid repeated freezing and thawing
- Quality Control Testing:
- 2 ug/lane SDS-PAGE Stained with Coomassie Blue
- Note:
- Result of activity analysis
-
- Application Image
- Functional Study
- SDS-PAGE
- Entrez GeneID:
- 1024
- Protein Accession#:
- NM_001260 (Gene ID : 1024);NM_005190.3 (Gene ID : 892)
- Gene Name:
- CDK8
- Gene Alias:
- K35,MGC126074,MGC126075
- Gene Description:
- cyclin-dependent kinase 8
- Omim ID:
- 603184
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq
- Other Designations:
- CDK8 protein kinase,OTTHUMP00000018158,cell division protein kinase 8,protein kinase K35
- Entrez GeneID:
- 892
- Protein Accession#:
- NM_001260 (Gene ID : 1024);NM_005190.3 (Gene ID : 892)
- Gene Name:
- CCNC
- Gene Alias:
- CycC
- Gene Description:
- cyclin C
- Omim ID:
- 123838
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000016897