NR1H2 polyclonal antibody
产品名称： NR1H2 polyclonal antibody
英文名称： NR1H2 polyclonal antibody
产品编号： PAB6690
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of NR1H2.
- Immunogen:
- A synthetic peptide corresponding to human NR1H2.
- Sequence:
- SSPTTSSLDTPLPGC
- Host:
- Goat
- Theoretical MW (kDa):
- 51
- Reactivity:
- Human
- Specificity:
- This antibody is expected to be specific to LXR beta and not to cross-react with LXR alpha.
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:64000)
Western blot (1-3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG.Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11896-901. Epub 2002 Aug 22.
- Applications
- Western Blot (Tissue lysate)
- NR1H2 polyclonal antibody (Cat # PAB6690) (1 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
- Entrez GeneID:
- 7376
- Protein Accession#:
- NP_009052
- Gene Name:
- NR1H2
- Gene Alias:
- LXR-b,LXRB,NER,NER-I,RIP15,UNR
- Gene Description:
- nuclear receptor subfamily 1, group H, member 2
- Omim ID:
- 600380
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995 [PubMed 7625741]).[supplied by OMIM
- Other Designations:
- LX receptor beta,liver X receptor beta,liver X receptor-beta,nuclear orphan receptor LXR-beta,oxysterols receptor LXR-beta,steroid hormone-nuclear receptor NER,ubiquitously-expressed nuclear receptor
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Atherosclerosis
- Calcinosis
- Cardiovascular Diseases
- Coronary Artery Disease
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Edema
- Encephalitis
- Genetic Predisposition to Disease
- Kidney Failure, Chronic
- Lymphoma, Non-Hodgkin
- Metabolic Syndrome X
- Neoplasms
- Obesity
- Osteoporosis