DUSP1 polyclonal antibody
产品名称： DUSP1 polyclonal antibody
英文名称： DUSP1 polyclonal antibody
产品编号： PAB24852
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of DUSP1.
- Immunogen:
- A synthetic peptide corresponding to DUSP1.
- Host:
- Rabbit
- Theoretical MW (kDa):
- 39
- Reactivity:
- Human
- Specificity:
- DUSP1 polyclonal antibody detects endogenous levels of DUSP1 protein.
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 1 mg/mL
- Purity:
- > 95% by SDS-PAGE
- Storage Buffer:
- In 1x PBS, pH 7.2 (0.05% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1000)
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Entrez GeneID:
- 1843
- Gene Name:
- DUSP1
- Gene Alias:
- CL100,HVH1,MKP-1,MKP1,PTPN10
- Gene Description:
- dual specificity phosphatase 1
- Omim ID:
- 600714
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq
- Other Designations:
- serine/threonine specific protein phosphatase
- Gene Pathway