Human Growth Factors & Cytokines
Recombinant Human HB-EGF





 





		Synonyms :
Heparin Binding EGF-like growth factor, HBEGF, Diphtheria toxin receptor, DTR



		Description :
HB-EGF is an EGF related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes, and certain tumor cells. The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. Recombinant human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extra-cellular EGF-like and heparin binding domains of the full length HB-EGF protein.



		Catalog #:
100-47



		Source :
E.coli



		Purity :
Greater than 95% by SDS-PAGE gel and HPLC analyses



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK 
YVKELRAPS CICHPGYHGE RCHGLSL 



		PubMed Link :
HB-EGF


Country of Origin :
USA
















        Size A
10μg
$80 
 


 



        Size B
50μg
$195 
 


 



        Size C
1mg
$1500 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.