Recombinant Human FGF-21

Catalog Number:
AF-100-42
Synonyms:
Fibroblast Growth Factor-21, FGFL
Description:
FGF-21是一种分泌型生长因子,属于FGF家族。这个家族的蛋白通过促进细胞的增殖和分化，在胎儿发育和产后生长，以及各种组织的再生过程中发挥着重要作用。FGF-21在辅助因子β-Klotho蛋白的存在下，通过FGFR1c和4受体进行信号传导，刺激脂肪细胞摄取胰岛素依赖的葡萄糖。重组人FGF-21是一个分子量为19.5 kDa的蛋白，由182个氨基酸残基组成。生产过程中的所有试剂均为非动物源性。
AA Sequence:
MLGQDMVSPE ATNSSSSSFS SPSSAGRHVR SYNHLQGDVR WRKLFSFTKY FLKIEKNGKV SGTKKENCPY SILEITSVEI GVVAVKAINS NYYLAMNKKG KLYGSKEFNN DCKLKERIEE NGYNTYASFN WQHNGRQMYV ALNGKGAPRR GQKTRRKNTS AHFLPMVVHS
Source:
E.coli
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.6 μg/ml, in the presence of murine Klotho.
 
 
 
 
Research Interests:


    

        

            

            
Angiogenesis/ Cardiovascular
            

            
FGF Superfamily
        
        

            

            
Proliferation
            
 
        
    


 
 
Country of Origin:
USA