SMAD1 monoclonal antibody (M05), clone 1C7
产品名称： SMAD1 monoclonal antibody (M05), clone 1C7
英文名称： SMAD1 monoclonal antibody (M05), clone 1C7
产品编号： H00004086-M05
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant SMAD1.
- Immunogen:
- SMAD1 (NP_005891, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCE
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG1 Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.84 KDa) .
- MSDS:
Download
- Applications
- Western Blot (Cell lysate)
- SMAD1 monoclonal antibody (M05), clone 1C7 Western Blot analysis of SMAD1 expression in Hela NE ( Cat # L013V3 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Immunoperoxidase of monoclonal antibody to SMAD1 on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 3 ug/ml]
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged SMAD1 is approximately 3ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 4086
- GeneBank Accession#:
- NM_005900
- Protein Accession#:
- NP_005891
- Gene Name:
- SMAD1
- Gene Alias:
- BSP1,JV4-1,JV41,MADH1,MADR1
- Gene Description:
- SMAD family member 1
- Omim ID:
- 601595
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq
- Other Designations:
- MAD, mothers against decapentaplegic homolog 1,Mad-related protein 1,SMAD, mothers against DPP homolog 1,Sma- and Mad-related protein 1,TGF-beta signaling protein 1,mothers against DPP homolog 1,transforming growth factor-beta signaling protein 1
- Gene Pathway
- Related Disease
- Cleft Lip
- Cleft Palate
- Diabetes Mellitus, Type 1
- Diabetic Nephropathies
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Hemochromatosis
- Hypertension, Pulmonary
- Kidney Failure, Chronic
- Neoplasm Recurrence, Local
- Neoplasms, Second Primary
- Obesity
- Ovarian Failure, Premature
- Polycystic Ovary Syndrome
- Puberty, Delayed
- Puberty, Precocious
- Thrombophilia
- Tobacco Use Disorder