RRP8 Rabbit pAb (APR28998N)
产品名称: RRP8 Rabbit pAb (APR28998N)
英文名称: RRP8 Rabbit pAb (APR28998N)
产品编号: APR28998N
产品价格: null
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围:
安诺伦(北京)生物科技有限公司
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分子量:Calculated MW: 50kDa Observed MW: 58KDa 稀释方法:WB 1:500 - 1:2000 总结:Essential component of the eNoSC (energy-dependent nucleolar silencing complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+/NADP(+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2 by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.