分子量：Calculated MW: 24kDa
Observed MW: 30kDa

细胞定位：Secreted, extracellular matrix, extracellular space

稀释方法：WB 1:500 - 1:2000
IHC 1:50 - 1:100

总结：Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.