PANK2抗体Applications
| In-house applications |
ELISA, WB, IHC, IP, IF Application not tested? Please see our Guarantee. |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
|
Images
Prev12Next
 HeLa cells were subjected to SDS PAGE followed by western blot with 11001-1-AP(PANK2 antibody) at dilution of 1:100 IP Result of anti-PANK2 (IP:11001-1-AP, 3ug; Detection:11001-1-AP 1:800) with mouse brain tissue lysate 9500ug. Immunohistochemical of paraffin-embedded human lung cancer using 11001-1-AP(PANK2 antibody) at dilution of 1:10 (under 10x lens) Immunofluorescent analysis of HepG2 cells using 11001-1-AP( PANK2 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
|
| Positive WB detected in |
HeLa cells, HepG2 cells, human brain tissue, MCF7 cells, mouse brain tissue, mouse lung tissue |
| Positive IP detected in |
Mouse brain tissue |
| Positive IHC detected in |
Human lung cancer tissue, human liver tissue |
| Positive IF detected in |
HepG2 cells |
| Recommended dilution |
WB : 1:200-1:2000
IP : 1:200-1:2000
IHC : 1:10-1:100
IF : 1:10-1:100 |
PANK2抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information PANK2抗体
| Immunogen |
PANK2 fusion protein ag1413 |
Full name |
Pantothenate kinase 2 |
Calculated molecular
weight |
63 kDa |
Observed molecular
weight |
59 kDa,48 kDa |
GenBank accession
number |
BC009421 |
Gene ID (NCBI) |
80025 |
| Gene symbol |
PANK2 |
Synonyms |
C20orf48, FLJ17232, HARP, hPanK2, HSS, NBIA1, PANK2, pantothenate kinase 2, Pantothenic acid kinase 2, PKAN |
Background
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Pantothenate kinase 2 (PANK2) is an essential regulatory enzyme in coenzyme A biosynthesis. PANK2 mutations cause pantothenate kinase-associated neurodegeneration (PKAN), which leads to pigmentary retinopathy, progressive dystonia and other abnormalities(PMID:20603201). PanK2 protein is localized to mitochondria of neurons in human brain, distinguishing it from other pantothenate kinases that do not possess mitochondrial-targeting sequences(PMID:15659606 ). It has 4 isoforms produced by alternative splicing and alternative initiation. PANK2抗体
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