AICDA monoclonal antibody, clone 2D3
产品名称： AICDA monoclonal antibody, clone 2D3
英文名称： AICDA monoclonal antibody, clone 2D3
产品编号： MAB1107
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinant AICDA.
- Immunogen:
- Recombinant protein corresponding to amino acids 1-54 of human AICDA.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG1, kappa
- Storage Buffer:
- In PBS, pH 7.4 (0.1% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.
Kotani A, Kakazu N, Tsuruyama T, Okazaki IM, Muramatsu M, Kinoshita K, Nagaoka H, Yabe D, Honjo T.Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1616-20. Epub 2007 Jan 24.
- 2.
- AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.
Larijani M, Petrov AP, Kolenchenko O, Berru M, Krylov SN, Martin A.Mol Cell Biol. 2007 Jan;27(1):20-30. Epub 2006 Oct 23.
- 3.
- The AID enzyme induces class switch recombination in fibroblasts.
Okazaki IM, Kinoshita K, Muramatsu M, Yoshikawa K, Honjo T.Nature. 2002 Mar 21;416(6878):340-5. Epub 2002 Mar 3.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of cell lysates of HepG2 (60 ug) and Ramos (60 ug) were resolved by SDS - PAGE , transferred to NC membrane and probed with AICDA monoclonal antibody , clone 2D3 (1 : 500) (Cat # MAB1107). Proteins were visualized using a goat anti - mouse secondary antibody conjugated to HRP and an ECL detection system.
- Entrez GeneID:
- 57379
- Gene Name:
- AICDA
- Gene Alias:
- AID,ARP2,CDA2,HIGM2
- Gene Description:
- activation-induced cytidine deaminase
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq
- Other Designations:
- activation-induced deaminase,integrated into Burkitt's lymphoma cell line Ramos
- Gene Pathway
- Related Disease
- Asthma
- Asthma
- Bronchial Hyperreactivity
- Gastritis, Atrophic
- Genetic Predisposition to Disease
- Helicobacter Infections
- Hematologic Diseases
- Hodgkin Disease
- Hypersensitivity, Immediate
- Immunologic Deficiency Syndromes
- Kidney Failure, Chronic
- Lymphoma, B-Cell
- Lymphoma, Follicular
- Lymphoma, Large B-Cell, Diffuse
- Lymphoproliferative Disorders
- Occupational Diseases
- Severe Combined Immunodeficiency
- Stomach Neoplasms
- Tobacco Use Disorder