HLA-G monoclonal antibody, clone MEM-G/9
产品名称: HLA-G monoclonal antibody, clone MEM-G/9
英文名称: HLA-G monoclonal antibody, clone MEM-G/9
产品编号: MAB3855
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant HLA-G.
- Immunogen:
- Recombinant protein corresponding to human HLA-G.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody reacts with native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells.
- Form:
- Liquid
- Concentration:
- 1 mg/mL
- Isotype:
- IgG1
- Storage Buffer:
- In PBS, pH 7.4 (15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (1-5 mg/mL)
ELISA (10 mg/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Regulatory role of tryptophan degradation pathway in HLA-G expression by human monocyte-derived dendritic cells.
Lopez AS, Alegre E, LeMaoult J, Carosella E, Gonzalez A.Mol Immunol. 2006 Jul;43(14):2151-60. Epub 2006 Feb 21.
- 2.
- The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules.
Gonen-Gross T, Achdout H, Arnon TI, Gazit R, Stern N, Horejsi V, Goldman-Wohl D, Yagel S, Mandelboim O.J Immunol. 2005 Oct 15;175(8):4866-74.
- 3.
- Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules.
Menier C, Saez B, Horejsi V, Martinozzi S, Krawice-Radanne I, Bruel S, Le Danff C, Reboul M, Hilgert I, Rabreau M, Larrad ML, Pla M, Carosella ED, Rouas-Freiss N.Hum Immunol. 2003 Mar;64(3):315-26.
- Applications
- Immunofluorescence
- Immunofluorescence staining of HLA-G1 transfectants (LCL-HLA-G1) using HLA-G monoclonal antibody, clone MEM-G/9 (Cat # MAB3855) Alexa Fluor® 488 Fab-fragment.
- Immunoprecipitation
- Immunoprecipitation of HLA-G from HLA-G1 transfectants (LCL-HLA-G1) by HLA-G monoclonal antibody, clone MEM-G/9 (Cat # MAB3855) and protein G. HLA-G was detected by HLA-G monoclonal antibody, clone 4H84 (Cat # MAB3858) and goat anti-mouse HRP in cell lysate (Lane 1) and in the immunoprecipitate (Lane 2).
- Entrez GeneID:
- 3135
- Gene Name:
- HLA-G
- Gene Alias:
- MHC-G
- Gene Description:
- major histocompatibility complex, class I, G
- Gene Ontology:
- Hyperlink
- Gene Summary:
- HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq
- Other Designations:
- HLA class I molecule,HLA-G histocompatibility antigen, class I, G,MHC class I antigen,OTTHUMP00000039485,b2 microglobulin
- Related Disease
- Abortion, Habitual
- Abortion, Spontaneous
- Anemia, Sickle Cell
- Arthritis, Juvenile Rheumatoid
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Autoimmune Diseases
- Behcet Syndrome
- Birth Weight
- Bronchial Hyperreactivity
- Carcinoma, Transitional Cell
- Cardiomyopathy, Dilated
- Cardiovascular Diseases
- Cervical Intraepithelial Neoplasia
- Cholestasis, Intrahepatic
- Chorioamnionitis
- Colitis, Ulcerative
- Coronary Aneurysm