EIF2AK2 (C-term) Peptide
产品名称： EIF2AK2 (C-term) Peptide
英文名称： EIF2AK2 (C-term) Peptide
产品编号： P3182
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of EIF2AK2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human EIF2AK2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice.
Peel AL, Bredesen DE.Neurobiol Dis. 2003 Oct;14(1):52-62.
- 2.
- Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR.
Kim SH, Gunnery S, Choe JK, Mathews MB.Oncogene. 2002 Dec 12;21(57):8741-8.
- 3.
- The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC.
Pang Q, Christianson TA, Keeble W, Koretsky T, Bagby GC.J Biol Chem. 2002 Dec 20;277(51):49638-43. Epub 2002 Oct 22.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of EIF2AK2 (arrow) using EIF2AK2 polyclonal antibody (Cat # PAB2144). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EIF2AK2 gene (Lane 2) (Origene Technologies).
- Western Blot
- The EIF2AK2 polyclonal antibody (Cat # PAB2144) is used in Western blot to detect EIF2AK2 in mouse uterus tissue lysate (Lane 1) and HepG2 cell lysate (Lane 2) .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with EIF2AK2 polyclonal antibody (Cat # PAB2144) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 5610
- Protein Accession#:
- NP_002750;Q52M43
- Gene Name:
- EIF2AK2
- Gene Alias:
- EIF2AK1,MGC126524,PKR,PRKR
- Gene Description:
- eukaryotic translation initiation factor 2-alpha kinase 2
- Omim ID:
- 176871
- Gene Ontology:
- Hyperlink
- Other Designations:
- OTTHUMP00000126954,double stranded RNA activated protein kinase,interferon-inducible elF2alpha kinase,protein kinase, interferon-inducible double stranded RNA dependent